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Redefining Heart HealthAround You.
Filming this video took place prior to COVID-19 pandemic
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Departments


Caregivers from the Heart and Vascular Institute's four departments - Cardiovascular Medicine, Cardiac Surgery, Vascular Surgery and Interventional Radiology - collaborate with other medical and surgical specialties to provide the highest level of patient care, research and education to patients with cardiac, vascular and related conditions. 

Research and Clinical Trials

Research is a core mission of Carle Heart and Vascular Institute (HVI). HVI works closely with the Stephen’s Family Clinical Research Institute to offer patients leading-edge therapies through clinical trials. Our physician investigators (cardiologists, cardiac surgeons, vascular surgeons and radiologists) are involved in multiple national and investigator-initiated studies that span the field of pharmacotherapy and interventional devices. Also, HVI is actively involved in translational research activities in collaboration with the Beckman Institute for Advanced Science and Technology.

Cryo AF Global Registry

The Cryo AF Global Registry is a prospective, global, multi-center, observational post-market registry (PMR). The purpose of this study is to evaluate and describe clinical performance and safety data in a broad patient population treated with a commercially available Arctic Front™ Family of Cardiac Cryoablation Catheters (hereafter referred to as "Arctic Front™ Cardiac Cryoablation Catheter System"). The cryoballoon ablation(CBA) procedure will be performed according to routine hospital practice. The study is expected to have a 24 month enrollment period. The follow up period is intended to align with standard practice and subjects will be followed for a minimum of 12 months post-procedure.

Pulmonary Embolism Response Team (PERT) Consortium Registry

The purpose of this registry (“the PERT Registry”) is to gather data on patients diagnosed with pulmonary embolism, treated by the Pulmonary Embolism Response Team (PERT) at each site and beyond for epidemiologic, therapeutic, quality assessment and outcomes research.

Early Dronedarone Versus Usual Care to Improve Outcomes in Persons With Newly Diagnosed Atrial Fibrillation (CHANGE-AFIB)

While there are several completed clinical trials that address treatment strategy in patients with symptomatic and recurrent AF, there are no randomized clinical trials that address treatment for first-detected AF. In usual care, these patients are started on an atrioventricular nodal blocking agent (beta-blocker or non-dihydropyridine calcium channel blocker) along with stroke prevention therapy. The investigators hypothesize that earlier administration of a well-tolerated antiarrhythmic drug proven to reduce hospitalization may result in improved cardiovascular outcomes and quality of life in patients first-detected AF. The purpose of this study is to determine if treatment with dronedarone on top of usual care is superior to usual care alone for the prevention of cardiovascular hospitalization or death from any cause in patients hospitalized with first-detected AF. All patients will be treated with guideline-recommended stroke prevention therapy according to the CHA2DS2-VASc score. The treatment follow-up period will be 12 months. There will be two follow-up visits. Consistent with the pragmatic nature of the trial, the first follow-up will occur between 3 -9 months and the 2nd will occur at 12 months (with a window of +/- 30 days). Approximately 3000 patients will be enrolled and randomly assigned (1:1) to study intervention. The study intervention will be dronedarone 400 mg twice daily in addition to usual care versus usual care alone.

SEE MORE CLINICAL TRIALS

Meet Our Team

With doctors practicing in 80 specialties at locations throughout the region, it’s easy to find the right healthcare team at Carle. Our mission is to serve people through high quality care, medical research and education.

MEET OUR TEAM

Online Appointment Scheduling

Online scheduling is now available. Find the provider and time that’s right for you.

Giving

Charitable gifts are used for numerous projects and programs that enhance the healthcare experience for heart patients and their loved ones.  With your support, we’ll take the steps necessary to keep our cardiovascular services beating strong.

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Related Events

Dec. 19, 2023
3:30 p.m.

Awards and Accreditations

Recognized among the nation’s top hospitals, Carle provides excellent healthcare while continuously improving to meet the needs of our patients.

    • IAC - Certified Echo-cardiogram Program
    • American College o Cardiology - Chest Pain Center