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Redefining CancerCare Around You.
Filming this video took place prior to COVID-19 pandemic

Research and Clinical Trials

Involved in national research for more than 30 years, Carle Cancer Institute offers its patients access to innovative ways to fight cancer through clinical trials. Clinical trials offer new insight into how to combat a disease like cancer and demonstrate new ways of preventing, treating, or possibly curing cancer.

Carle Cancer Institute provides access to clinical trials for several types of cancer including but not limited to breast, lung, colon, melanoma, prostate, and ovarian cancer. We are also actively involved in national prevention clinical trials per cancer type. In addition, we offer symptom management program to address the quality of life of cancer patients.

Implementation and Effectiveness Trial of HN-STAR (HN-STAR)

People who have been treated for head and neck cancer (HNC survivors) can experience serious consequences from their cancer and its treatment, ongoing risks of new cancers, and other unrelated illnesses. These concerns pose challenges to the provision of comprehensive care to HNC survivors. We created HN-STAR to facilitate and tailor the ongoing care of HNC survivors. Survivors use HN-STAR on a computer or tablet to answer questions about symptoms and health concerns before a routine visit with a cancer care provider. During the clinic visit, the provider uses HN-STAR to see evidence-based recommendations for managing each concern reported by the survivor. The provider and survivor discuss recommendations and select appropriate actions (e.g., testing, referrals, prescriptions, self-management). HN-STAR produces a survivorship care plan that includes all reported concerns and the actions selected in clinic. The survivorship care plan is given to the survivor and the primary care provider. Three months, six months, and nine months later, the survivor uses HN-STAR from home (or clinic) to report their concerns again, and a new survivorship care plan is created each time. Our trial randomizes =30 oncology practices from the National Community Oncology Research Program to use HN-STAR or provide usual care to 350 recent survivors of head and neck cancer. We hypothesize that survivors in the HN-STAR arm will have greater improvement in patient-centered outcomes (including cancer-related well-being, symptoms, and patient activation) over one year compared to survivors in the usual care arm, measured by surveys at baseline and one year later. We also hypothesize that survivors in the HN-STAR arm will be more likely to receive care that is aligned with evidence-based recommendations during the year of the study than survivors in the usual care arm. Our final aim investigates the implementation of HN-STAR in clinical practice, using interviews and surveys of survivors, providers, and other clinic staff to understand the feasibility, acceptability, appropriateness, and other aspects of providing survivorship care to head and neck cancer survivors.

Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer (M&M)

This study will examine the association between low muscle mass (myopenia) at diagnosis and chemotherapy toxicity in older adults with newly diagnosed advanced colorectal cancer.

An Internet-based Program to Help Cancer Survivors Manage Pain (IMPACTS)

To determine whether an Internet-based pain coping skills program plus enhanced usual care, compared to enhanced usual care alone, yields significant improvements in the co-primary outcomes of pain severity (as measured by the Brief Pain Inventory (BPI)) and pain interference (also measured by the BPI) from baseline to the post-intervention assessment for cancer survivors with persistent pain.


Meet Our Team

With doctors practicing in 80 specialties at locations throughout the region, it’s easy to find the right healthcare team at Carle. Our mission is to serve people through high quality care, medical research and education.



Charitable gifts are used for numerous projects and programs that enhance the healthcare experience for cancer patients and their loved ones. With your support, we’ll continue to work to eliminate cancer through excellence in diagnosis, treatment, research and education. 


Related Events

Oct. 21, 2021
8 a.m.
Oct. 21, 2021
10:30 a.m.

Awards and Accreditations

Recognized among the nation’s top hospitals, Carle provides excellent healthcare while continuously improving to meet the needs of our patients.

  • National Accreditation Program for Breast Cancer
  • Commission on Cancer
  • ACR - Breast Ultrasound Accredited Company
  • QOPI Certified