skip to main content
Main Site Navigation
Top of main content
Redefining CancerCare Around You.
Filming this video took place prior to COVID-19 pandemic
WATCH VIDEO
AUDIO DESCRIPTIONS

Research and Clinical Trials

Involved in national research for more than 30 years, Carle Cancer Institute offers its patients access to innovative ways to fight cancer through clinical trials. Clinical trials offer new insight into how to combat a disease like cancer and demonstrate new ways of preventing, treating, or possibly curing cancer.

Carle Cancer Institute provides access to clinical trials for several types of cancer including but not limited to breast, lung, colon, melanoma, prostate, and ovarian cancer. We are also actively involved in national prevention clinical trials per cancer type. In addition, we offer symptom management program to address the quality of life of cancer patients.

Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

This phase III trial studies how well lenalidomide and dexamethasone works with or without daratumumab in treating patients with high-risk smoldering myeloma. Drugs used in chemotherapy, such as lenalidomide and dexamethasone, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as daratumumab, may induce changes in the body's immune system and may interfere with the ability of tumor cells to grow and spread. Giving lenalidomide and dexamethasone with daratumumab may work better in treating patients with smoldering myeloma.

Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial

This phase III trial compares the combination of four drugs (daratumumab, bortezomib, lenalidomide and dexamethasone) to the use of a three drug combination (daratumumab, lenalidomide and dexamethasone). Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Chemotherapy drugs, such as lenalidomide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Daratumumab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. Anti-inflammatory drugs, such as dexamethasone lower the body's immune response and are used with other drugs in the treatment of some types of cancer. Adding bortezomib to daratumumab, lenalidomide, and dexamethasone may be more effective in shrinking the cancer or preventing it from returning, compared to continuing on daratumumab, lenalidomide, and dexamethasone.

Implementing a Virtual Tobacco Treatment for Cancer Patients in Community Oncology Practices

A research study by the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) is evaluating the use of video counseling nationwide to help cancer patients who smoke to quit and stay smoke-free. Up to 30% of cancer patients are smoking tobacco at the time of diagnosis, and the majority continue to smoke. Counseling to help patients stop smoking is not part of standard care for cancer. This is a particular concern in community-based hospitals and clinics, which care for 80% of all cancer patients in the US. In the outbreak of the new coronavirus disease, COVID-19, cancer patients are at high risk of severe respiratory illness from infection because cancer and its treatments weaken their immune systems. The World Health Organization cautions that smokers are likely to be more vulnerable to COVID-19 as smoking behavior means that fingers (and possibly contaminated cigarettes) are in contact with lips, which increases the possibility of transmission of the virus from hand to mouth. Smokers may also already have lung disease or reduced lung capacity, which would significantly increase the risk of developing a respiratory illness. To learn if you are eligible for the study, complete the application below, or for more information visit: https://ecog-acrin.org/news-and-info/press-releases/ecog-acrin-offers-stop-smoking-study-for-cancer-patients-seeking-to-lower-covid-19-risk.

SEE MORE CLINICAL TRIALS

Meet Our Team

With doctors practicing in 80 specialties at locations throughout the region, it’s easy to find the right healthcare team at Carle. Our mission is to serve people through high quality care, medical research and education.

MEET OUR TEAM

Giving

Charitable gifts are used for numerous projects and programs that enhance the healthcare experience for cancer patients and their loved ones. With your support, we’ll continue to work to eliminate cancer through excellence in diagnosis, treatment, research and education. 

DONATE NOW GIVING AT CARLE

Related Events

Awards and Accreditations

Recognized among the nation’s top hospitals, Carle provides excellent healthcare while continuously improving to meet the needs of our patients.

  • National Accreditation Program for Breast Cancer
  • Commission on Cancer
  • ACR - Breast Ultrasound Accredited Company
  • QOPI Certified