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Redefining Heart HealthAround You.
Filming this video took place prior to COVID-19 pandemic


Caregivers from the Heart and Vascular Institute's four departments - Cardiovascular Medicine, Cardiac Surgery, Vascular Surgery and Interventional Radiology - collaborate with other medical and surgical specialties to provide the highest level of patient care, research and education to patients with cardiac, vascular and related conditions. 

Research and Clinical Trials

Research is a core mission of Carle Heart and Vascular Institute (HVI). HVI works closely with the Stephen’s Family Clinical Research Institute to offer patients leading-edge therapies through clinical trials. Our physician investigators (cardiologists, cardiac surgeons, vascular surgeons and radiologists) are involved in multiple national and investigator-initiated studies that span the field of pharmacotherapy and interventional devices. Also, HVI is actively involved in translational research activities in collaboration with the Beckman Institute for Advanced Science and Technology.

A Study of Milvexian in Participants After a Recent Acute Coronary Syndrome (LIBREXIA-ACS)

The purpose of this study is to evaluate that milvexian is superior to placebo, in addition to standard-of-care, in reducing the risk of major adverse cardiovascular event (MACE) (the composite of cardiovascular [CV] death, myocardial infarction [MI], and ischemic stroke).

Distal Evaluation of Functional Performance With Intravascular Sensors to Assess the Narrowing Effect: Guided Physiologic Stenting (DEFINE GPS)

Multi-center, prospective, randomized controlled study comparing PCI guided by angiography versus iFR Co-Registration using commercially available Philips pressure guidewires and the SyncVision co-registration system, employing an adaptive design study for interim sample size re-estimation.

Post-approval Study of Transcarotid Artery Revascularization in Standard Risk Patients With Significant Carotid Artery Disease

The study objective is to evaluate real world usage of the ENROUTE Transcarotid Stent when used with the ENROUTE Transcarotid Neuroprotection System in patients at standard risk for adverse events from carotid endarterectomy


Meet Our Team

With doctors practicing in 80 specialties at locations throughout the region, it’s easy to find the right healthcare team at Carle. Our mission is to serve people through high quality care, medical research and education.


Online Appointment Scheduling

Online scheduling is now available. Find the provider and time that’s right for you.


Charitable gifts are used for numerous projects and programs that enhance the healthcare experience for heart patients and their loved ones.  With your support, we’ll take the steps necessary to keep our cardiovascular services beating strong.


Related Events

Awards and Accreditations

Recognized among the nation’s top hospitals, Carle provides excellent healthcare while continuously improving to meet the needs of our patients.

    • IAC - Certified Echo-cardiogram Program
    • American College o Cardiology - Chest Pain Center